ALLMAX - Agmatine + Sulfate, 34 g

Agmatine is a small molecule that the body naturally makes from the amino acid arginine. Agmatine is a decarboxylated metabolite of arginine. Simply put, agmatine is what arginine becomes in the body.

Agmatine has a dual function:

A) Selective inhibition of the enzyme that breaks down nitric oxide – the result, increased nitric oxide (NO).

B) Direct stimulation of NO. Increased NO creates an environment conducive to increased nutrient intake, improved metabolic waste removal, and most importantly, increased overall performance.

NITRIC OXIDE - Vascularity, blood volume, pump:
Agmatine modulates nitric oxide (NO) in several ways. It stimulates some types of nitric oxide synthase (NOS) while inhibiting others, in this respect it is considered "selective". This is essential for the proper functioning of polyamine biosynthesis pathways. There are 3 forms of NOS, iNOS (inducible), nNOS (neuronal) and eNOS (endothelial).

Research suggests that agmatine is unique in that it stimulates eNOS while limiting iNOS and eNOS. This is a very important distinction for those of us looking for increased vascularity, increased blood flow and volume. Among bodybuilders, agmatine has become legendary for its ability to produce long-lasting pumps. It has even been named " perpetual pump » by some.

SOME HAVE EVEN BAPTIZED IT " PERPETUAL PUMP » .

Lean Body Mass - Improved Insulin Response:
Some research has shown that agmatine helps improve insulin production, leading to a better insulin response. This can help to have positive effects in achieving body composition goals. While the research is still considered preliminary, it could indicate an improvement in insulin response; if so, this could impact a leaner, harder physique.

Agmatine has been shown to affect the release of catecholamines (epinephrine > norepinephrine > dopamine). These are chemical messengers that play an important role in energy production, fat loss, and stress.

There are well-established effects that epinephrine can have on the body, including:

• Increased stamina
• Improve performance
• Decrease in body fat

ANTI-OXIDANT ACTION - Reduction of AGEs (Advanced Glycation End-Products):

Some research has shown that agmatine has an antioxidant role. There can be no greater source of free radical accumulation than that seen in the daily activity of the athlete. The simple stress that the body experiences when you are an athlete in the trenches (i.e. in the gym, on the field, etc.) could ultimately have significant detrimental effects with continued accumulation. Agmatine may offer some protection against the detrimental effects that free radicals can have on the body.

STRESS - The cortisol response:

Agmatine has shown anxiolytic (anxiety-relieving) activity in some research and may offer potential control of high cortisol levels in the athlete's stressful life.

AGMATINE SAFETY:

Agmatine is a natural substance produced by different areas of the body. Indeed, several medical conditions appear to be associated with abnormally low levels of Agmatine in various areas of the body.

Research in adult rats that consumed large amounts of agmatine sulfate for three months showed no negative effects on their behavior or organs. The only effects noted were small but significant reductions in body weight and blood pressure. While human clinical trials have shown that taking 3.5 g of agmatine sulfate per day is safe for 21 days, two researchers took 2.6 g of agmatine sulfate per day for five years and had no adverse effects. Thus, agmatine sulfate is likely safe when taken in doses of 2 to 3 g per day for five years or more in healthy people.